Women's Transition Formula. During perimenopause, it is essential for women to understand the impact of normal hormone fluctuations on their quality of life. As estrogen and progesterone begin to decline in perimenopause, hormones begin to fluctuate dramatically. Scientists have evidence that estrogen levels will ultimately drop 40 to 60 percent, while progesterone can decline even more dramatically. It is clear that nutrition and exercise can significantly affect health during perimenopause and that poor nutrition and a sedentary lifestyle parallel a tremendous increase in symptoms during this phase of life.